Article
beta-Catenin and ras oncogenes detect most human colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2003
Zhang Bin, Ougolkov Andrei, Yamashita Kaname, Takahashi Yutaka, Mai Masayoshi, Minamoto Toshinari
Abstract excerpt
UNLABELLED: PURPOSE AND STUDY DESIGN: Recent studies have shown that beta-catenin translocated into the cell nucleus functions like an oncogene. Accumulating evidence suggests that activation of the beta-catenin oncogenic signaling cascade along with its twin, the K-ras cascade, may exert syngeneic or synergistic effects on tumor development and progression. In the study reported here, we analyzed oncogenic...
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