Article
The molecular nature of spontaneous mutations at the hprt locus in the radiosensitive CHO mutant xrs-5.
Mutation research - 26 Mar 1996
Schwartz J L, Porter R C, Hsie A W
Abstract excerpt
The radiosensitive mutant xrs-5, a derivative of the Chinese hamster ovary (CHO) K1 cell, is defective in DNA double-strand break rejoining ability and in V(D)J recombination. The radiosensitivity and defective repair phenotype are complemented by the 80-kDa subunit of the Ku protein. We determined the nature of the mutations that develop spontaneously at the hprt locus in this cell line using both multiplex PCR...
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