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XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.

Nucleic acids research - 1 Jul 1998

Errami A, He D M, Friedl A A, Overkamp W J, Morolli B, Hendrickson E A, Eckardt-Schupp F, Oshimura M, Lohman P H, Jackson S P, Zdzienicka M Z

Abstract excerpt

DNA-dependent protein kinase (DNA-PK) plays an important role in DNA double-strand break (DSB) repair and V(D)J recombination. We have isolated a new X-ray-sensitive CHO cell line, XR-C1, which is impaired in DSB repair and which was assigned to complementation group 7, the group that is defective in the XRCC7 / SCID ( Prkdc ) gene encoding the catalytic subunit of DNA-PK (DNA-PKcs). Consistent with this...

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Identifiers

PMID: 9628911
DOI: 10.1093/nar/26.13.3146
PMCID: PMC147672

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.PMID 9628911Read ↗

A new X-ray sensitive CHO cell mutant of ionizing radiation group 7,XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination.Semantic proximity Read ↗

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