Article
XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation.
Nucleic acids research - 1 Jul 1998
Errami A, He D M, Friedl A A, Overkamp W J, Morolli B, Hendrickson E A, Eckardt-Schupp F, Oshimura M, Lohman P H, Jackson S P, Zdzienicka M Z
Abstract excerpt
DNA-dependent protein kinase (DNA-PK) plays an important role in DNA double-strand break (DSB) repair and V(D)J recombination. We have isolated a new X-ray-sensitive CHO cell line, XR-C1, which is impaired in DSB repair and which was assigned to complementation group 7, the group that is defectiv...
Topics
- Animals
- CHO Cells
- Chromosomes, Human, Pair 8
- Cricetinae
- DNA Damage
- DNA-Activated Protein Kinase
- DNA-Binding Proteins
- Genetic Complementation Test
- Humans
- Hybrid Cells
- Immunoglobulin Joining Region
- Immunoglobulin Variable Region
- Mutagens