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Article

Dissecting the fidelity of bacteriophage RB69 DNA polymerase: site-specific modulation of fidelity by polymerase accessory proteins.

Genetics - 1 Nov 2002

Bebenek Anna, Carver Geraldine T, Dressman Holly Kloos, Kadyrov Farid A, Haseman Joseph K, Petrov Vasiliy, Konigsberg William H, Karam Jim D, Drake John W

Abstract excerpt

Bacteriophage RB69 encodes a replicative B-family DNA polymerase (RB69 gp43) with an associated proofreading 3' exonuclease. Crystal structures have been determined for this enzyme with and without DNA substrates. We previously described the mutation rates and kinds of mutations produced in vivo by the wild-type (Pol(+) Exo(+)) enzyme, an exonuclease-deficient mutator variant (Pol(+) Exo(-)), mutator variants...

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Identifiers

PMID: 12454051
DOI: 10.1093/genetics/162.3.1003
PMCID: PMC1462346

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