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Article

DNA polymerase fidelity: from genetics toward a biochemical understanding.

Genetics - 1 Apr 1998

Goodman M F, Fygenson K D

Abstract excerpt

This review summarizes mutagenesis studies, emphasizing the use of bacteriophage T4 mutator and antimutator strains. Early genetic studies on T4 identified mutator and antimutator variants of DNA polymerase that, in turn, stimulated the development of model systems for the study of DNA polymerase fidelity in vitro. Later enzymatic studies using purified T4 mutator and antimutator polymerases were essential in...

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Identifiers

PMID: 9560367
DOI: 10.1093/genetics/148.4.1475
PMCID: PMC1460091

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