DNA polymerase fidelity: from genetics toward a biochemical understanding.

doi:10.1093/genetics/148.4.1475

Back to search

Article

DNA polymerase fidelity: from genetics toward a biochemical understanding.

Genetics - 1 Apr 1998

Goodman M F, Fygenson K D

Abstract excerpt

This review summarizes mutagenesis studies, emphasizing the use of bacteriophage T4 mutator and antimutator strains. Early genetic studies on T4 identified mutator and antimutator variants of DNA polymerase that, in turn, stimulated the development of model systems for the study of DNA polymerase...

Topics

Bacteriophage T4
DNA-Directed DNA Polymerase
Humans
Mutation
Substrate Specificity
Viral Proteins

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.