Article
Retention of replication fidelity by a DNA polymerase functioning in a distantly related environment.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 1997
Dressman H K, Wang C C, Karam J D, Drake J W
Abstract excerpt
The primary structures of the replicative DNA polymerases (gp43s) of bacteriophage T4 and its distant phylogenetic relative RB69 are diverged, retaining only 61% identity and 74% similarity. Nevertheless, RB69 gp43 substitutes effectively for T4 gp43 in T4 DNA replication in vivo. We show here th...
Topics
- Bacteriophage T4
- DNA Replication
- DNA, Viral
- DNA-Directed DNA Polymerase
- Mutation
- RNA-Binding Proteins
- Repressor Proteins
- Viral Proteins