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Article

The roles of Tyr391 and Tyr619 in RB69 DNA polymerase replication fidelity.

Journal of molecular biology - 20 Apr 2007

Jacewicz Agata, Makiela Karolina, Kierzek Andrzej, Drake John W, Bebenek Anna

Abstract excerpt

In the family-B DNA polymerase of bacteriophage RB69, the conserved aromatic palm-subdomain residues Tyr391 and Tyr619 interact with the last primer-template base-pair. Tyr619 interacts via a water-mediated hydrogen bond with the phosphate of the terminal primer nucleotide. The main-chain amide of Tyr391 interacts with the corresponding template nucleotide. A hydrogen bond has been postulated between Tyr391 and...

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Identifiers

PMID: 17321543
DOI: 10.1016/j.jmb.2007.01.067
PMCID: PMC1925234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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