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Article

Characterization of a replicative DNA polymerase mutant with reduced fidelity and increased translesion synthesis capacity.

Nucleic acids research - 1 Jul 2008

Zhong Xuejun, Pedersen Lars C, Kunkel Thomas A

Abstract excerpt

Changing a highly conserved amino acid in motif A of any of the four yeast family B DNA polymerases, DNA polymerase alpha, delta, epsilon or zeta, results in yeast strains with elevated mutation rates. In order to better understand this phenotype, we have performed structure-function studies of homologous mutants of RB69 DNA polymerase (RB69 pol), a structural model for family B members. When Leu415 in RB69 pol...

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Identifiers

PMID: 18503083
DOI: 10.1093/nar/gkn312
PMCID: PMC2475618

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Source receipt: pubmed, retrieved 7 Sept 2026.

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