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Article

Antimutator variants of DNA polymerases.

Critical reviews in biochemistry and molecular biology - 1 Dec 2011

Herr Alan J, Williams Lindsey N, Preston Bradley D

Abstract excerpt

Evolution balances DNA replication speed and accuracy to optimize replicative fitness and genetic stability. There is no selective pressure to improve DNA replication fidelity beyond the background mutation rate from other sources, such as DNA damage. However, DNA polymerases remain amenable to amino acid substitutions that lower intrinsic error rates. Here, we review these 'antimutagenic' changes in DNA...

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Identifiers

PMID: 21977975
DOI: 10.3109/10409238.2011.620941
PMCID: PMC3725746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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