Article
The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL).
The Journal of cell biology - 9 Jul 2001
West K A, Zhang H, Brown M C, Nikolopoulos S N, Riedy M C, Horwitz A F, Turner C E
Abstract excerpt
The small GTPases of the Rho family are intimately involved in integrin-mediated changes in the actin cytoskeleton that accompany cell spreading and motility. The exact means by which the Rho family members elicit these changes is unclear. Here, we demonstrate that the interaction of paxillin via its LD4 motif with the putative ARF-GAP paxillin kinase linker (PKL) (Turner et al., 1999), is critically involved in...
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