Article
Ras-induced serine phosphorylation of the focal adhesion protein paxillin is mediated by the Raf-->MEK-->ERK pathway.
Experimental cell research - 15 Jul 2003
Woodrow Melissa A, Woods Douglas, Cherwinski Holly M, Stokoe David, McMahon Martin
Abstract excerpt
Cells transformed by Ras and Raf display dramatic alterations in cell morphology, adhesion, and intracellular architecture. Consequently, we investigated whether Ras or Raf might influence the behavior of proteins known to be involved in the assembly and integrity of focal adhesion complexes that play a crucial role in many of these processes. We identified Raf-induced serine phosphorylation of the adaptor...
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