Article
Inhibition of RhoA by p120 catenin.
Nature cell biology - 1 Sept 2000
Anastasiadis P Z, Moon S Y, Thoreson M A, Mariner D J, Crawford H C, Zheng Y, Reynolds A B
Abstract excerpt
RhoA organizes actin stress fibres and is necessary for cell transformation by oncogenes such as src and ras. Moreover, RhoA is implicated in cadherin clustering during the formation of adherens junctions. The catenin p120 has also been implicated in cadherin clustering through an unknown mechanism. Here we show that p120 selectively inhibits RhoA activity in vitro and in vivo. RhoA inhibition and the interaction...
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