Article
Translocation of cortactin to the cell periphery is mediated by the small GTPase Rac1.
Journal of cell science - 1 Aug 1998
Weed S A, Du Y, Parsons J T
Abstract excerpt
Small GTPases of the Rho family regulate signaling pathways that control actin cytoskeletal structures. In Swiss 3T3 cells, RhoA activation leads to stress fiber and focal adhesion formation, Rac1 to lamellipoda and membrane ruffles, and Cdc42 to microspikes and filopodia. Several downstream mole...
Topics
- 3T3 Cells
- Actins
- Animals
- Base Sequence
- Biological Transport, Active
- Cell Membrane
- Cortactin
- DNA Primers
- Enzyme Activation
- GTP Phosphohydrolases
- GTP-Binding Proteins
- Mice
- Microfilament Proteins
- Mutation
- Platelet-Derived Growth Factor
- Protein Serine-Threonine Kinases
- Signal Transduction
- Tetradecanoylphorbol Acetate