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Article

Paxillin Binding to a Conserved Sequence Motif in the α4 Integrin Cytoplasmic Domain

1 Jul 2000

Abstract excerpt

alpha(4)beta(1) integrin-mediated cell adhesion results in increased cell migration, reduced cell spreading, and focal adhesion formation relative to other beta(1) integrins. Paxillin, a signaling adapter protein, binds tightly to the alpha(4) cytoplasmic domain and is implicated in alpha(4) integrin signaling. We now report the mapping of a paxillin-binding site in the alpha(4) cytoplasmic domain and an...

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PMID: 10781578
DOI: 10.1074/jbc.m000388200

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