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Article

Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.

PLoS genetics - 1 Sept 2014

Huang Yanmei, McNeil Gerard P, Jackson F Rob

Abstract excerpt

The Drosophila homolog of Casein Kinase I δ/ε, DOUBLETIME (DBT), is required for Wnt, Hedgehog, Fat and Hippo signaling as well as circadian clock function. Extensive studies have established a critical role of DBT in circadian period determination. However, how DBT expression is regulated remain...

Topics

Alleles
Animals
Casein Kinase 1 epsilon
Circadian Clocks
Circadian Rhythm
Darkness
Drosophila
Drosophila Proteins
Gene Expression Regulation
Light
Period Circadian Proteins
Protein Biosynthesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 25211129
DOI: 10.1371/journal.pgen.1004536
PMCID: PMC4161311

Genes

DBT
RBM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-25211129-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Translational regulation of the DOUBLETIME/CKIδ/ε kinase by LARK contributes to circadian period modulation.PMID 25211129Read ↗

Drosophila doubletime mutations which either shorten or lengthen the period of circadian rhythms decrease the protein kinase activity of casein kinase I.Semantic proximity Read ↗

Role for Slimb in the degradation of Drosophila Period protein phosphorylated by Doubletime.Semantic proximity Read ↗

A role for casein kinase 2alpha in the Drosophila circadian clock.Semantic proximity Read ↗

Activating PER repressor through a DBT-directed phosphorylation switch.Semantic proximity Read ↗

Identification of Light-Sensitive Phosphorylation Sites on PERIOD That Regulate the Pace of Circadian Rhythms in Drosophila.Semantic proximity Read ↗

The dramatic impact of the PER-DBT interaction on circadian timekeeping and temperature compensationSemantic proximity Read ↗

Drosophila and vertebrate casein kinase Idelta exhibits evolutionary conservation of circadian function.Semantic proximity Read ↗

Ribosomal s6 kinase cooperates with casein kinase 2 to modulate the Drosophila circadian molecular oscillator.Semantic proximity Read ↗

The phospho-occupancy of an atypical SLIMB-binding site on PERIOD that is phosphorylated by DOUBLETIME controls the pace of the clock.Semantic proximity Read ↗

Casein kinase 1 promotes synchrony of the circadian clock network.Semantic proximity Read ↗

Two novel doubletime mutants alter circadian properties and eliminate the delay between RNA and protein in Drosophila.Semantic proximity Read ↗

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