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Article

Population variation in linkage disequilibrium across the COMT gene considering promoter region and coding region variation.

Human genetics - 1 Dec 2002

DeMille Mellissa M C, Kidd Judith R, Ruggeri Valeria, Palmatier Meg A, Goldman David, Odunsi Adekunle, Okonofua Friday, Grigorenko Elena, Schulz Leslie O, Bonne-Tamir Batsheva, Lu Ru-Band, Parnas Josef, Pakstis Andrew J, Kidd Kenneth K

Abstract excerpt

Catechol-O-methyl transferase (COMT) catalyzes the first step in one of the major pathways in the degradation of catecholamines. The COMT gene on chromosome 22 has been considered a candidate gene for many neuropsychiatric disorders, in part because an exon 4 single nucleotide polymorphism (SNP) in COMT causes an amino acid substitution associated with significantly altered enzyme activity. This functional...

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Source

Identifiers

PMID: 12436243
DOI: 10.1007/s00439-002-0809-0

Genes

COMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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