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Article

Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs.

PloS one - 1 Jan 2009

Nackley Andrea G, Shabalina Svetlana A, Lambert Jason E, Conrad Mathew S, Gibson Dustin G, Spiridonov Alexey N, Satterfield Sarah K, Diatchenko Luda

Abstract excerpt

Catechol-O-methyltransferase (COMT) is an enzyme that plays a key role in the modulation of catechol-dependent functions such as cognition, cardiovascular function, and pain processing. Three common haplotypes of the human COMT gene, divergent in two synonymous and one nonsynonymous (val(158)met) position, designated as low (LPS), average (APS), and high pain sensitive (HPS), are associated with experimental pain...

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Source

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Identifiers

PMID: 19365560
DOI: 10.1371/journal.pone.0005237
PMCID: PMC2664927

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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