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In Silico Prediction of the Effects of Nonsynonymous Single Nucleotide Polymorphisms in the Human Catechol-O-Methyltransferase (COMT) Gene.

Cell biochemistry and biophysics - 1 Jun 2020

Yilmaz Akin, Çetin İhsan

Abstract excerpt

Catechol-O-methyltransferase (COMT) enzyme performs transfer of methyl group to endogenous and exogenous catechol substrates. The COMT enzyme draws interest because of its association with psychiatric, neurological and cardiovascular diseases, and several cancers. Moreover, many prescribed drugs, supplements, and their metabolites are used as substrates of COMT enzyme. The human COMT gene has 226 nonsynonymous...

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Catechol O-Methyltransferase
Codon, Terminator
Frameshift Mutation
INDEL Mutation
Leucine

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PMID: 32236879
DOI: 10.1007/s12013-020-00905-6

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