Article
Linkage disequilibrium on the COMT gene in French schizophrenics and controls.
American journal of medical genetics - 15 Oct 1999
de Chaldée M, Laurent C, Thibaut F, Martinez M, Samolyk D, Petit M, Campion D, Mallet J
Abstract excerpt
Catechol-O-methyltransferase (COMT) catalyzes the degradation of catecholamines and could therefore play a role in the etiology of schizophrenia. Moreover, microdeletions including the COMT locus have been found in schizophrenics presenting typical features of the velo-cardio-facial syndrome. In the present work, five single-strand conformation polymorphisms were detected in exons of the COMT gene. The linkage...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.