Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.

doi:10.1016/s0006-3223(99)00098-0

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Article

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.

Biological psychiatry - 15 Aug 1999

Palmatier M A, Kang A M, Kidd K K

Abstract excerpt

BACKGROUND: Catechol-O-methyltransferase (COMT) has been investigated as a candidate gene in many neurologic disorders involving catecholaminergic systems. The NlaIII restriction site polymorphism (RSP) at COMT is a G<-->A (site absent<-->site present) single nucleotide polymorphism (SNP) at nucleotide 322/472 (in the short or long mRNA) that results in a Val<-->Met polymorphism at amino acid 108/158 (in soluble...

Topics

Alleles
Animals
Catechol O-Methyltransferase
Central Nervous System Diseases
Female
Gene Frequency
Genetic Linkage
Genetic Markers
Humans
Male
Mental Disorders
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Primates
Racial Groups
Reference Values

Source

Open in PubMed

Identifiers

PMID: 10459407
DOI: 10.1016/s0006-3223(99)00098-0

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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