Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jun 2005

Cyran Shawn A, Yiannoulos Georgia, Buchsbaum Anna M, Saez Lino, Young Michael W, Blau Justin

Abstract excerpt

The Period (PER), Timeless (TIM), and Double-Time (DBT) proteins are essential components of one feedback loop in the Drosophila circadian molecular clock. PER and TIM physically interact. Coexpression of PER and TIM promotes their nuclear accumulation and influences the activity of DBT: although DBT phosphorylates and destabilizes PER, this is suppressed by TIM. Experiments using Drosophila cells in culture have...

Read the complete abstract on PubMed

Topics

ARNTL Transcription Factors
Active Transport, Cell Nucleus
Animals
Basic Helix-Loop-Helix Transcription Factors
CLOCK Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Casein Kinase 1 epsilon

Cell Nucleus

Circadian Rhythm

Drosophila

Drosophila Proteins

Glycogen Synthase Kinase 3

Immunohistochemistry

Models, Biological

Mutation

Nuclear Proteins

Period Circadian Proteins

Transcription Factors

Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15930393
DOI: 10.1523/JNEUROSCI.0263-05.2005
PMCID: PMC1361277

Genes

DBT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The double-time protein kinase regulates the subcellular localization of the Drosophila clock protein period.PMID 15930393Read ↗

A PER/TIM/DBT interval timer for Drosophila's circadian clock.Semantic proximity Read ↗

Post-translational regulation and nuclear entry of TIMELESS and PERIOD are affected in new timeless mutant.Semantic proximity Read ↗

Block in nuclear localization of period protein by a second clock mutation, timeless.Semantic proximity Read ↗

TIMELESS is an important mediator of CK2 effects on circadian clock function in vivo.Semantic proximity Read ↗

CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythmsSemantic proximity Read ↗

The timSL mutant of the Drosophila rhythm gene timeless manifests allele-specific interactions with period gene mutants.Semantic proximity Read ↗

double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.Semantic proximity Read ↗

The F-box protein slimb controls the levels of clock proteins period and timeless.Semantic proximity Read ↗

Isolation of timeless by PER protein interaction: defective interaction between timeless protein and long-period mutant PERL.Semantic proximity Read ↗

Molecular control of circadian behavioral rhythms.Semantic proximity Read ↗

Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.Semantic proximity Read ↗

A TIMELESS-independent function for PERIOD proteins in the Drosophila clock.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.