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Article

Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS.

Current biology : CB - 11 Jan 2021

Kula-Eversole Elżbieta, Lee Da Hyun, Samba Ima, Yildirim Evrim, Levine Daniel C, Hong Hee-Kyung, Lear Bridget C, Bass Joseph, Rosbash Michael, Allada Ravi

Abstract excerpt

The timing of behavior under natural light-dark conditions is a function of circadian clocks and photic input pathways, but a mechanistic understanding of how these pathways collaborate in animals is lacking. Here we demonstrate in Drosophila that the Phosphatase of Regenerating Liver-1 (PRL-1) sets period length and behavioral phase gated by photic signals. PRL-1 knockdown in PDF clock neurons dramatically...

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Identifiers

PMID: 33157022
DOI: 10.1016/j.cub.2020.10.013
PMCID: PMC7855481

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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