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Article

Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.

Development (Cambridge, England) - 1 Dec 2002

Hamblet Natasha S, Lijam Nardos, Ruiz-Lozano Pilar, Wang Jianbo, Yang Yasheng, Luo Zhenge, Mei Lin, Chien Kenneth R, Sussman Daniel J, Wynshaw-Boris Anthony

Abstract excerpt

The murine dishevelled 2 (Dvl2) gene is an ortholog of the Drosophila segment polarity gene Dishevelled, a member of the highly conserved Wingless/Wnt developmental pathway. Dvl2-deficient mice were produced to determine the role of Dvl2 in mammalian development. Mice containing null mutations in Dvl2 present with 50% lethality in both inbred 129S6 and in a hybrid 129S6-NIH Black Swiss background because of...

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Identifiers

PMID: 12421720
DOI: 10.1242/dev.00164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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