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Article

Genetic analysis of disheveled 2 and disheveled 3 in human neural tube defects.

Journal of molecular neuroscience : MN - 1 Mar 2013

De Marco Patrizia, Merello Elisa, Consales Alessandro, Piatelli Gianluca, Cama Armando, Kibar Zoha, Capra Valeria

Abstract excerpt

Neural tube defects are severe malformations affecting 1/1,000 live births. The planar cell polarity pathway controls the neural tube closure and has been implicated in the pathogenesis of neural tube defects both in animal models and human cohorts. In mouse disruption of Dvl2 alone (Dvl2 (-/-)) or Dvl2 and Dvl3 (Dvl2 (-/-); Dvl3 (+/-), Dvl2 (+/-);...

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Source

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Identifiers

PMID: 22892949
DOI: 10.1007/s12031-012-9871-9
PMCID: PMC3566388

Genes

DVL2
DVL3

Variants

Provenance

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