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Article

HAND proteins: molecular mediators of cardiac development and congenital heart disease.

Trends in cardiovascular medicine - 1 Jan 2000

Srivastava D

Abstract excerpt

Congenital heart defects are the clinical manifestation of anomalies in embryonic cardiac development. Such defects occur in distinct regions or chambers of the heart. A molecular framework in which to consider cardiac development and congenital heart disease in a segmental fashion has begun to emerge. dHAND and eHAND are two related basic helix-loop-helix transcription factors that are expressed in a...

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Identifiers

PMID: 10189962
DOI: 10.1016/s1050-1738(98)00033-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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HAND proteins: molecular mediators of cardiac development and congenital heart disease.PMID 10189962Read ↗

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In-Silico analysis of HAND subclass bHLH transcription factor in CardiogenesisSemantic proximity Read ↗

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Genetic and Cellular Interaction During Cardiovascular Development Implicated in Congenital Heart DiseasesSemantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

A Decade of Advances in the Molecular Embryology and Genetics Underlying Congenital Heart DefectsSemantic proximity Read ↗

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.Semantic proximity Read ↗

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.Semantic proximity Read ↗

Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.Semantic proximity Read ↗

HAND transcription factors cooperatively specify the aorta and pulmonary trunk.Semantic proximity Read ↗

A bHLH code for cardiac morphogenesis.Semantic proximity Read ↗

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