HAND proteins: molecular mediators of cardiac development and congenital heart disease.

doi:10.1016/s1050-1738(98)00033-4

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

HAND proteins: molecular mediators of cardiac development and congenital heart disease.

Trends in cardiovascular medicine - 1 Jan 2000

Srivastava D

Abstract excerpt

Congenital heart defects are the clinical manifestation of anomalies in embryonic cardiac development. Such defects occur in distinct regions or chambers of the heart. A molecular framework in which to consider cardiac development and congenital heart disease in a segmental fashion has begun to emerge. dHAND and eHAND are two related basic helix-loop-helix transcription factors that are expressed in a...

Topics

Animals
Aorta
Aorta, Thoracic
Basic Helix-Loop-Helix Transcription Factors
Branchial Region
DNA-Binding Proteins
Gene Expression Regulation, Developmental
Heart
Heart Defects, Congenital
Heart Ventricles
Helix-Loop-Helix Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mesoderm

Mice

Morphogenesis

Mutation

Neural Crest

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 10189962
DOI: 10.1016/s1050-1738(98)00033-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HAND proteins: molecular mediators of cardiac development and congenital heart disease.PMID 10189962Read ↗

The bHLH factors, dHAND and eHAND, specify pulmonary and systemic cardiac ventricles independent of left-right sidedness.Semantic proximity Read ↗

A GATA-dependent right ventricular enhancer controls <i>dHAND</i> transcription in the developing heartSemantic proximity Read ↗

In-Silico analysis of HAND subclass bHLH transcription factor in CardiogenesisSemantic proximity Read ↗

Molecular pathways controlling heart development.Semantic proximity Read ↗

Genetic and Cellular Interaction During Cardiovascular Development Implicated in Congenital Heart DiseasesSemantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

A Decade of Advances in the Molecular Embryology and Genetics Underlying Congenital Heart DefectsSemantic proximity Read ↗

The Hand1 and Hand2 transcription factors regulate expansion of the embryonic cardiac ventricles in a gene dosage-dependent manner.Semantic proximity Read ↗

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.Semantic proximity Read ↗

Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis.Semantic proximity Read ↗

HAND transcription factors cooperatively specify the aorta and pulmonary trunk.Semantic proximity Read ↗

A bHLH code for cardiac morphogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.