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Article

Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells.

Development (Cambridge, England) - 1 Jul 2004

Kaartinen Vesa, Dudas Marek, Nagy Andre, Sridurongrit Somyoth, Lu Min Min, Epstein Jonathan A

Abstract excerpt

Cardiac neural crest cells are multipotent migratory cells that contribute to the formation of the cardiac outflow tract and pharyngeal arch arteries. Neural crest-related developmental defects account for a large proportion of congenital heart disorders. Recently, the genetic bases for some of these disorders have been elucidated, and signaling pathways required for induction, migration and differentiation of...

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Identifiers

PMID: 15226263
DOI: 10.1242/dev.01214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells.PMID 15226263Read ↗

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Ankrd11, a chromatin regulator and a KBG syndrome risk gene, is a critical regulator of cardiac neural crest cell biology and heart developmentSemantic proximity Read ↗

N-cadherin is required for neural crest remodeling of the cardiac outflow tract.Semantic proximity Read ↗

Cardiac Neural Crest Expression of Hand2 Regulates Outflow and Second Heart Field DevelopmentSemantic proximity Read ↗

The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart functionSemantic proximity Read ↗

The Cardiac Neural Crest Cells in Heart Development and Congenital Heart DefectsSemantic proximity Read ↗

Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest.Semantic proximity Read ↗

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