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Article

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation.

Developmental biology - 15 Nov 2001

Yamagishi H, Yamagishi C, Nakagawa O, Harvey R P, Olson E N, Srivastava D

Abstract excerpt

Nkx2.5/Csx and dHAND/Hand2 are conserved transcription factors that are coexpressed in the precardiac mesoderm and early heart tube and control distinct developmental events during cardiogenesis. To understand whether Nkx2.5 and dHAND may function in overlapping genetic pathways, we generated mouse embryos lacking both Nkx2.5 and dHAND. Mice heterozygous for mutant alleles of Nkx2.5 and dHAND were viable....

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Identifiers

PMID: 11784028
DOI: 10.1006/dbio.2001.0417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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