Article
SUMO-1 protease-1 regulates gene transcription through PML.
Molecular cell - 1 Oct 2002
Best Jennifer L, Ganiatsas Soula, Agarwal Sadhana, Changou Austin, Salomoni Paolo, Shirihai Orian, Meluh Pamela B, Pandolfi Pier Paolo, Zon Leonard I
Abstract excerpt
During a screen to identify c-Jun activators, we isolated a cysteine protease, SuPr-1, that induced c-Jun-dependent transcription independently of c-Jun phosphorylation. SuPr-1 is a member of a new family of proteases that hydrolyze the ubiquitin-like modifier, SUMO-1. SuPr-1 hydrolyzed SUMO-1-modified forms of the promyelocytic leukemia gene product, PML, and altered the subcellular distribution of PML in...
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