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Article

PML positively regulates interferon gamma signaling

30 Nov 2010

Abstract excerpt

PML, also known as TRIM19, belongs to the family encoding a characteristic RBCC/TRIM motif comprising several cysteine-rich zinc-binding domains (RING and B-boxes) and a coiled-coil domain. The RBCC domain and the covalent modification of PML by the small ubiquitin-like modifier (SUMO) are required for PML localization within the nuclear bodies (NBs). Analysis of PML(-/-) mice provided evidence for a...

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Identifiers

PMID: 21115099
DOI: 10.1016/j.biochi.2010.11.005

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