Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PIAS proteins promote SUMO-1 conjugation to STAT1.

Blood - 1 Nov 2003

Ungureanu Daniela, Vanhatupa Sari, Kotaja Noora, Yang Jie, Aittomaki Saara, Jänne Olli A, Palvimo Jorma J, Silvennoinen Olli

Abstract excerpt

Signal transducer and activator of transcription 1 (STAT1) is a critical mediator of interferon-gamma (IFN-gamma)-induced transcription that is regulated through posttranslational modifications and through transacting proteins such as protein inhibitor of activated STAT1 (PIAS1). PIAS proteins have been shown to function as E3-type small ubiquitin-like modifier (SUMO) ligases, and sumoylation has been identified...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HeLa Cells
Share to Interferon-gamma
Share to Protein Processing, Post-Translational

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to STAT1 Transcription Factor

Share to SUMO-1 Protein

Share to Trans-Activators

Share to Transcriptional Activation

Share to Vanadates

Source

Identifiers

PMID: 12855578
DOI: 10.1182/blood-2002-12-3816

Genes

STAT1
PIAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIAS proteins promote SUMO-1 conjugation to STAT1.PMID 12855578Read ↗

SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation.Semantic proximity Read ↗

Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function.Semantic proximity Read ↗

PIAS family in cancer: from basic mechanisms to clinical applicationsSemantic proximity Read ↗

Interferon, restriction factors and SUMO pathwaysSemantic proximity Read ↗

The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction.Semantic proximity Read ↗

Sumoylation: a regulatory protein modification in health and disease.Semantic proximity Read ↗

The post-translational modification, SUMOylation, and cancer (Review)Semantic proximity Read ↗

An E3-like factor that promotes SUMO conjugation to the yeast septins.Semantic proximity Read ↗

SUMO-1 modification of MEF2A regulates its transcriptional activity.Semantic proximity Read ↗

Virus infection triggers SUMOylation of IRF3 and IRF7, leading to the negative regulation of type I interferon gene expression.Semantic proximity Read ↗

Protein Post‐Translational Modification‐Mediated Control of Type I Interferon Cascade SignalingSemantic proximity Read ↗

Sumoylation in Physiology, Pathology and TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.