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Article

SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation.

The Journal of biological chemistry - 8 Aug 2003

Rogers Richard S, Horvath Curt M, Matunis Michael J

Abstract excerpt

The PIAS (protein inhibitors of activated STAT) family of proteins were first discovered as inhibitors of activated signal transducers and activators of transcription (STATs). More recently these proteins have been shown to function as E3 ligases that promote the SUMO modification of a number of...

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Source

Identifiers

PMID: 12764129
DOI: 10.1074/jbc.M301344200

Genes

STAT1
PIAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-12764129-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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SUMO modification of STAT1 and its role in PIAS-mediated inhibition of gene activation.PMID 12764129Read ↗

PIAS proteins promote SUMO-1 conjugation to STAT1.Semantic proximity Read ↗

PIAS family in cancer: from basic mechanisms to clinical applicationsSemantic proximity Read ↗

Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating p27Kip1Semantic proximity Read ↗

Novel signal transducer and activator of transcription 1 mutation disrupts small ubiquitin-related modifier conjugation causing gain of function.Semantic proximity Read ↗

Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life.Semantic proximity Read ↗

PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73.Semantic proximity Read ↗

Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin.Semantic proximity Read ↗

Arginine methylation of STAT1 regulates its dephosphorylation by T cell protein tyrosine phosphatase.Semantic proximity Read ↗

Novel Gain-of-Function Mutation in Stat1 Sumoylation Site Leads to CMC/CID Phenotype Responsive to RuxolitinibSemantic proximity Read ↗

The 'PINIT' motif, of a newly identified conserved domain of the PIAS protein family, is essential for nuclear retention of PIAS3L.Semantic proximity Read ↗

Ligand binding reduces SUMOylation of the peroxisome proliferator-activated receptor γ (PPARγ) activation function 1 (AF1) domain.Semantic proximity Read ↗

An E3-like factor that promotes SUMO conjugation to the yeast septins.Semantic proximity Read ↗

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