Article
The IL-6 family of cytokines modulates STAT3 activation by desumoylation of PML through SENP1 induction.
Biochemical and biophysical research communications - 11 Jul 2008
Ohbayashi Norihiko, Kawakami Shiho, Muromoto Ryuta, Togi Sumihito, Ikeda Osamu, Kamitani Shinya, Sekine Yuichi, Honjoh Tsutomu, Matsuda Tadashi
Abstract excerpt
Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.