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Article

Sumoylation is critical for DJ-1 to repress p53 transcriptional activity.

FEBS letters - 2 Apr 2008

Fan Jun, Ren Haigang, Fei Erkang, Jia Nali, Ying Zheng, Jiang Peng, Wu Mian, Wang Guanghui

Abstract excerpt

Sumoylation is an important post-translational modification, which is also involved in the pathogenesis of many neurodegenerative diseases. We previously reported that DJ-1 decreases Bcl-2 associated X protein expression through repressing p53 transcriptional activity. Here we show that DJ-1(K130R), the non-sumoylatable mutant form of DJ-1, shifts from nucleus to cytoplasm, fails to repress p53 transcriptional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18339323
DOI: 10.1016/j.febslet.2008.03.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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