Article
APC and CTNNB1 mutations in a large series of sporadic colorectal carcinomas stratified by the microsatellite instability status.
Scandinavian journal of gastroenterology - 1 Oct 2002
Løvig T, Meling G I, Diep C B, Thorstensen L, Norheim Andersen S, Lothe R A, Rognum T O
Abstract excerpt
BACKGROUND: Adenomatous polyposis coli (APC) and beta-catenin (encoded by CTNNB1) are important components in the WNT signalling pathway, a pathway altered in nearly all colorectal tumours. Conflicting results are reported on whether APC mutations are less common in tumours with a high degree of microsatellite instability (MSI-H) than in microsatellite stable (MSS) ones, and whether mutations in the regulatory...
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