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Article

Mutations within Wnt pathway genes in sporadic colorectal cancers and cell lines.

International journal of cancer - 15 Oct 2006

Suraweera Nirosha, Robinson James, Volikos Emmanuoil, Guenther Thomas, Talbot Ian, Tomlinson Ian, Silver Andrew

Abstract excerpt

Wnt signaling pathway activation via mutation of genetic components, commonly adenomatous polyposis coli (APC), has a major role in colorectal cancer (CRC). Most components have not been assessed for mutation in sporadic CRC. We have analyzed AXIN2, CK1alpha, DKK1, GSK-3beta, SOX17, LRP6 and PPP2R1B, beta-catenin and APC in a collection of sporadic CRCs (n = 47) and CRC cell lines (CLs; n = 26). The CRC set was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16708370
DOI: 10.1002/ijc.22046

Genes

APC
AXIN2
DKK1
LRP6
SOX17

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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