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Molecular Genetic Analysis of 103 Sporadic Colorectal Tumours in Czech Patients

25 Aug 2011

Abstract excerpt

The Czech Republic has one of the highest incidences of colorectal cancer (CRC) in Europe. To evaluate whether sporadic CRCs in Czech patients have specific mutational profiles we analysed somatic genetic changes in known CRC genes (APC, KRAS, TP53, CTNNB1, MUTYH and BRAF, loss of heterozygosity (LOH) at the APC locus, microsatellite instability (MSI), and methylation of the MLH1 promoter) in 103 tumours from 102...

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PMID: 21901162
DOI: 10.1371/journal.pone.0024114

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