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Article

Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.

BMC cancer - 15 Dec 2005

Lüchtenborg Margreet, Weijenberg Matty P, Wark Petra A, Saritas A Merdan, Roemen Guido M J M, van Muijen Goos N P, de Bruïne Adriaan P, van den Brandt Piet A, de Goeij Anton F P M

Abstract excerpt

BACKGROUND: The early to intermediate stages of the majority of colorectal tumours are thought to be driven by aberrations in the Wnt (APC, CTNNB1) and Ras (K-ras) pathways. A smaller proportion of cancers shows mismatch repair deficiency. The aim of this study was to analyse the co-occurrence of these genetic alterations in relation to tumour and patient characteristics. METHODS: In a group of 656 unselected...

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Identifiers

PMID: 16356174
DOI: 10.1186/1471-2407-5-160
PMCID: PMC1334229

Genes

APC
CTNNB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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