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Article

The majority of β-catenin mutations in colorectal cancer is homozygous.

BMC cancer - 28 Oct 2020

Arnold Alexander, Tronser Moritz, Sers Christine, Ahadova Aysel, Endris Volker, Mamlouk Soulafa, Horst David, Möbs Markus, Bischoff Philip, Kloor Matthias, Bläker Hendrik

Abstract excerpt

BACKGROUND: β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal cancer (CRC). Previous animal studies provide an explanation for this observation. They showed that CTNNB1 mutations induced transformation in the colon only when CTNNB1 was homozygously mutated...

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Source

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Identifiers

PMID: 33115416
DOI: 10.1186/s12885-020-07537-2
PMCID: PMC7594410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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