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Article

Effect of β-catenin alterations in the prognosis of patients with sporadic colorectal cancer.

Journal of cancer research and therapeutics - 1 Jan 2000

Rafael Sara, Veganzones Silvia, Vidaurreta Marta, de la Orden Virginia, Maestro Maria Luisa

Abstract excerpt

CONTEXT: Wnt pathway activation represents a critical step in the etiology of most of colorectal cancer (CRC) and it is commonly due to mutations in the APC gene, which originates the loss of β-catenin regulatory function. It has been suggested that APC inactivation or β-catenin alteration have similar effects in tumor progression in CRC tumorigenesis. AIMS: The aim of this study was to analyze the frequency of...

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PMID: 25313745
DOI: 10.4103/0973-1482.139161

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APC

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