Article
Screening for microsatellite instability target genes in colorectal cancers.
Journal of medical genetics - 1 Nov 2002
Vilkki S, Launonen V, Karhu A, Sistonen P, Västrik I, Aaltonen L A
Abstract excerpt
BACKGROUND: Defects in the DNA repair system lead to genetic instability because replication errors are not corrected. This type of genetic instability is a key event in the malignant progression of HNPCC and a subset of sporadic colon cancers and mutation rates are particularly high at short rep...
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