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Article

Screening for microsatellite instability target genes in colorectal cancers.

Journal of medical genetics - 1 Nov 2002

Vilkki S, Launonen V, Karhu A, Sistonen P, Västrik I, Aaltonen L A

Abstract excerpt

BACKGROUND: Defects in the DNA repair system lead to genetic instability because replication errors are not corrected. This type of genetic instability is a key event in the malignant progression of HNPCC and a subset of sporadic colon cancers and mutation rates are particularly high at short repetitive sequences. Somatic deletions of coding mononucleotide repeats have been detected, for example, in the...

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Source

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Identifiers

PMID: 12414815
DOI: 10.1136/jmg.39.11.785
PMCID: PMC1735006

Genes

BAX
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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