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Article

Prevalence of mutations in APC, CTNNB1, and BRAF in Tunisian patients with sporadic colorectal cancer.

Cancer genetics and cytogenetics - 1 Nov 2008

Bougatef Karim, Ouerhani Slah, Moussa Amel, Kourda Nadia, Coulet Florence, Colas Chrystelle, Lahely Yannick Blondeau, Najjar Tawfik, Ben Jilani Sarra, Benammar-Elgaaied Amel, Soubrier Florent, Marrakchi Raja

Abstract excerpt

Sporadic colorectal tumorigenesis is caused by alterations in the Wnt (APC, CTNNB1) and Ras pathways. Our objective was to analyze the occurrence of these genetic alterations in relation to tumor and patient characteristics. The prevalence of somatic alteration in the hot-spot regions of the APC, BRAF, and CTNNB1 genes was investigated in 48 unselected and unrelated Tunisian patients with sporadic colorectal...

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Source

Identifiers

PMID: 18992635
DOI: 10.1016/j.cancergencyto.2008.06.016

Genes

APC
CTNNB1
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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