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Article

DNA damage-induced inhibition of securin expression is mediated by p53.

The Journal of biological chemistry - 3 Jan 2003

Zhou Yunli, Mehta Kshama R, Choi Andrew P, Scolavino Staci, Zhang Xun

Abstract excerpt

Tumor suppressor p53 induces the cellular response to DNA damage mainly by regulating expression of its downstream target genes. The human securin is an anaphase inhibitor, preventing premature chromosome separation through inhibition of separase activity. It is also known as the product of the human pituitary tumor-transforming gene, pttg, a proto-oncogene. Here we report that the expression of human securin is...

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Source

Identifiers

PMID: 12403781
DOI: 10.1074/jbc.M203793200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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DNA damage-induced inhibition of securin expression is mediated by p53.PMID 12403781Read ↗

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Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere DivisionSemantic proximity Read ↗

Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activitySemantic proximity Read ↗

Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere DivisionSemantic proximity Read ↗

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