Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A potential role for PTTG/securin in the developing human fetal brain

1 Sept 2003

Abstract excerpt

Human securin, known also as PTTG, has established oncogenic and cell cycle regulatory functions. PTTG/securin transforms cells in vitro, inhibits sister chromatid separation, and regulates secretion of fibroblast growth factor-2. FGF-2 is a key regulator of CNS development and PTTG/securin expression has been reported in murine fetal brain. We examined the expression and function of securin and FGF-2 in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hedgehog Signaling Pathway Studies
Share to Neurofibromatosis and Schwannoma Cases
Share to Pituitary Gland Disorders and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12958169
DOI: 10.1096/fj.02-0948com

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A potential role for PTTG/securin in the developing human fetal brainPMID 12958169Read ↗

Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere DivisionSemantic proximity Read ↗

Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere DivisionSemantic proximity Read ↗

Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells.Semantic proximity Read ↗

Pituitary tumor-transforming gene and its binding factor in endocrine cancerSemantic proximity Read ↗

Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.Semantic proximity Read ↗

Pituitary Tumor Transforming Gene (PTTG) Regulates Placental JEG-3 Cell Division and Survival: Evidence from Live Cell ImagingSemantic proximity Read ↗

Mutations in CDK 5 RAP 2 cause Seckel syndromeSemantic proximity Read ↗

Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells.Semantic proximity Read ↗

Characterization of the role of Sp1 and NF-Y in differential regulation of PTTG/securin expression in tumor cells.Semantic proximity Read ↗

DNA damage-induced inhibition of securin expression is mediated by p53.Semantic proximity Read ↗

PTTG's C-terminal PXXP motifs modulate critical cellular processes in vitro.Semantic proximity Read ↗

Expression of PTTG (Pituitary Tumor Transforming Gene) in Esophageal CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.