Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of securin promotes colorectal cancer cell death via a p53-independent pathway after radiation.

Chemico-biological interactions - 15 Dec 2007

Chiu Shu-Jun, Hsu Tzu-Sheng, Chao Jui-I

Abstract excerpt

Securin has been shown to regulate genomic stability; nevertheless, the role of securin on the cytotoxicity after radiation is still unclear. Exposure to 1-10 Gy X-ray radiation induced cell death in RKO colorectal cancer cells. The protein levels of securin, p53, and p21 were elevated by radiation. The proteins of phosphorylation of p53 at serine-15, which located on the nuclei of cancer cells, were highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Line, Tumor
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplasm Proteins

Share to Securin

Share to Signal Transduction

Share to Tumor Suppressor Protein p53

Share to Up-Regulation

Source

Identifiers

PMID: 17854787
DOI: 10.1016/j.cbi.2007.07.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Expression of securin promotes colorectal cancer cell death via a p53-independent pathway after radiation.PMID 17854787Read ↗

Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activitySemantic proximity Read ↗

DNA damage-induced inhibition of securin expression is mediated by p53.Semantic proximity Read ↗

Knockdown of <scp>S</scp>ec8 promotes cell‐cycle arrest at <scp>G</scp><sub>1</sub>/<scp>S</scp> phase by inducing p21 via control of <scp>FOXO</scp> proteinsSemantic proximity Read ↗

Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.Semantic proximity Read ↗

Enhancement of methyl methanesulfonate-induced base excision repair in the presence of selenomethionine on p53-dependent pathway.Semantic proximity Read ↗

Gamma-irradiation induces matrix metalloproteinase II expression in a p53-dependent mannerSemantic proximity Read ↗

Radiation-induced DNA damage response and resistance in colorectal cancer stem-like cellsSemantic proximity Read ↗

Comparable radiation sensitivity in p53 wild-type and p53 deficient tumor cells associated with different cell death modalitiesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.