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Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity

18 Aug 2006

Abstract excerpt

Genetic instability (GI) is a hallmark feature of tumor development. Securin, also known as pituitary tumor transforming gene (PTTG), is a mitotic checkpoint protein which is highly expressed in numerous cancers, is associated with tumor invasiveness, and induces GI in thyroid cells. We used fluorescence inter-simple sequence repeat PCR to assess GI caused primarily by DNA breakage events in 19 colorectal tumors....

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PMID: 17071631
DOI: 10.1093/carcin/bgl202

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