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Article

PTTG/securin activates expression of p53 and modulates its function.

1 Jan 2004

Abstract excerpt

BACKGROUND: Pituitary tumor transforming gene (PTTG) is a novel oncogene that is expressed abundantly in most tumors. Overexpression of PTTG induces cellular transformation and promotes tumor formation in nude mice. PTTG has been implicated in various cellular processes including sister chromatid separation during cell division as well as induction of apoptosis through p53-dependent and p53-independent...

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PMID: 15242522
DOI: 10.1186/1476-4598-3-18

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