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Article

Overexpressed pituitary tumor-transforming gene causes aneuploidy in live human cells.

Endocrinology - 1 Nov 2003

Yu Run, Lu Wenge, Chen Jiandong, McCabe Chris J, Melmed Shlomo

Abstract excerpt

The mammalian securin, pituitary tumor-transforming gene (PTTG), is overexpressed in several tumors and transforms cells in vitro and in vivo. To test the hypothesis that PTTG overexpression causes aneuploidy, enhanced green fluorescent protein (EGFP)-tagged PTTG (PTTG-EGFP) was expressed in human H1299 cancer cells (with undetectable endogenous PTTG expression) and mitosis of individual live cells observed....

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Identifiers

PMID: 12960092
DOI: 10.1210/en.2003-0305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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