Article

Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere Division

2001-11-01

Abstract excerpt

Tumorigenic pituitary tumor transforming gene (PTTG) is a mammalian homolog of Xenopus securin that inhibits chromatid separation, is overexpressed in many human tumor types, and mediates transcriptional activation. Loss of yeast securin Pds1p or Drosophila securin pimples is lethal. Here we show that mice lacking PTTG (PTTG −/−) are, surprisingly, viable and fertile; but they have testicular and splenic hypoplasi...

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Literature Corpus work: 339ae400-3b1f-5e5b-9649-093eb7f2469f
DOI: 10.1210/me.15.11.1870

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Mice Lacking Pituitary Tumor Transforming Gene Show Testicular and Splenic Hypoplasia, Thymic Hyperplasia, Thrombocytopenia, Aberrant Cell Cycle Progression, and Premature Centromere DivisionDOI 10.1210/me.15.11.1870Read

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