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Article

Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts.

The Journal of biological chemistry - 16 Jul 2010

Hsu Yi-Hsin, Liao Li-Jen, Yu Chuan-Hang, Chiang Chun-Pin, Jhan Jing-Ru, Chang Lien-Cheng, Chen Yann-Jang, Lou Pei-Jen, Lin Jing-Jer

Abstract excerpt

Pituitary tumor transforming gene (PTTG1, securin) is involved in cell-cycle control through inhibition of sister-chromatid separation. Elevated levels of PTTG1 were found to be associated with many different tumor types that might be involved in late stage tumor progression. However, the role of PTTG1 in early stage of tumorigenesis is unclear. Here we utilized the adenovirus expression system to deliver PTTG1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20452981
DOI: 10.1074/jbc.M109.096255
PMCID: PMC2903424

Genes

PTTG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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