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Article

Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.

Nature genetics - 1 Oct 2002

Bernal Juan A, Luna Rosa, Espina Agueda, Lázaro Icíar, Ramos-Morales Francisco, Romero Francisco, Arias Carmen, Silva Augusto, Tortolero María, Pintor-Toro José A

Abstract excerpt

The gene PTTG1 (encoding the pituitary tumor-transforming 1 protein) is overexpressed in several different tumor types, is tumorigenic in vivo and shows transcriptional activity. The PTTG1 protein is cell-cycle regulated and was identified as the human securin (a category of proteins involved in the regulation of sister-chromatid separation) on the basis of biochemical similarities with the Pds1p protein of...

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Source

Identifiers

PMID: 12355087
DOI: 10.1038/ng997

Genes

PTTG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Human securin interacts with p53 and modulates p53-mediated transcriptional activity and apoptosis.PMID 12355087Read ↗

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